As the curator of the Evergreen Museum, the soft-spoken Professor Smedley-Smythe is often the first locals turn to in matters of scientific inquiry. Though very experienced and intelligent, he can be a bit literal-minded and miss the meaning of words. He has a keen appreciation for art, believing no work of it is worthless.
- The Artful Dodger!
- Monster Mania!
- Search and Rescue!
- Science Friction
- The Headline Hunter! (flashback)
- Moving In! (mentioned)
- Easy Money!
- The One That Got Away! (gibberish voice only)
- The Professor's first name is only mentioned once, in his first appearance.
- Professor Smedley-Smythe mentions having a younger brother.
- In the Canadian-French version of the cartoon, Professor Smedley-Smythe's name is Professeur Barbichette.
- Main article: Professor Smedley-Smythe/Gallery